Definition of Clinically Significant Macular Edema (CSME) by Dev1 | Sep 6, 2023 | Bookmarking Post, CLINICAL DISTINCTIONS | 0 comments Bookmark Please login to bookmarkClosePlease login Any retinal edema within 1/3DD (500 um) of the fovea. Any hard exudates within 1/3DD (500 um) of the fovea with associated retinal edema. Retinal edema with an area of at least 1DD (1500 um) within 1DD (1500 um) of the fovea.